Tjimpuna has worked across several mediums including painting, linocut prints and batik, but her chosen medium is ceramics.
In 2012 she was a finalist in the indigenous Ceramic Art Awards at Shepparton Art Museum. Tjimpuna uses traditional patterns that relate to rockhole (tjukula) or sand dune (tali), and also paints the Tjukurpa of her mother;s country - Piltati, near Kanpi in the APY Lands. Other pieces are her personal walka or design. These designs are drawn from batik patterns and from her own interpretation of images from country and ceremony.
In 2011 Tjimpuna's ceramics were featured in an Ernabella exhibition at the South Australian Museum. She undertook a residency at the JamFactory in the same year. In 2012 Tjimpuna participated in the Australian Ceramic Triennale in Adelaide.
Tjimpuna and Derek Thompson were awarded a New Work grant by the Australian Council for the Arts and in 2013 undertook a big pot in Ji gdezhen, China. This work was exhibited in 2014 at Sydney's prestigious Sabbia Gallery. Tjimpuna has also travelled to Korea and Signapore for her art practice. in early 2015 Tjimpuna and Derek returned to Jingdezhen, and the work made then was exhibited with Sabbia Gallery in Sydney and at the Australian Ceramic Triennale in Canberra in June and July 2015.
In 2016 Ernabella was a key contributor to the collaborative ceramics installation created for the 2016 Indigenous Ceremic Art Award. The work involved seven women potters telling the important Seven Sisters Tjukurpa and was exhibited at Shepparton Art Museum. In 2016 Tjimpuna also exhibited in the Pukatjalanguru kungka tjuta kunpu warkarinytja - Ernabella wome: Strong work, together exhibition at Sabbia Gallery.
Tjimpuna's artwork has been acquired for the collections of the National Museum of Australia, Australian National Gallery, Queensland Art Gallery, and Museum of Ethnology, Osaka, Japan.
